There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent suffering transmission and make analgesia. Thus, medicine like clonidine that focus on alpha-2 receptors can affect the transmission of suffering. Clonidine treats large hypertension by stimulating https://www.proleviate.com/post/the-new-pain-killer-conolidine