A comprehensive literature evaluate of research involving 1995 and 2018 was conducted using the Digital databases PubMed and EBSCO Host. Searches have been executed making use of the next conditions: complete knee arthroplasty (TKA); cyclooxygenase-two inhibitors; bracing; Actual physical therapy; fat loss; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/