There exists a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to decrease afferent soreness transmission and generate analgesia. As a result, drugs like clonidine that goal alpha-two receptors can influence the transmission of soreness. Applies to clonidine: oral https://salvadorx136qym9.wikiexpression.com/user