At the moment, there are two styles of reports on itaconate: Irg1−/− macrophages as well as the regulatory effect of itaconate derivatives. These two results ended up complementary and disclosed the regulatory mechanisms of itaconate associated alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription issue 3 (ATF3) https://alfredi665ykv9.blogolenta.com/profile